Valeska Weber was born in Rendsburg.

After studying at the Freiburg Acting School, she played at the Städtische Bühnen Freiburg, the Landesbühne Hannover, the Stadttheater Dortmund, the Volkstheater Rostock and the Staatstheater Kassel. During this time she played, among others, Hermia from "A Midsummer Night's Dream", Betty Dullfeet from "Arturo Ui", Wickie from "Wickie und die starken Männer", Véronique from "The God of Carnage" and la Femme in "La voix humaine". She has worked with directors such as Adriana Altaras, Rudolf Koloc, Paul Esterhazy, Stephan Müller, Hartmut el Kurdi and Johanna Weißert.

Since 2011 she has been teaching at the Kassel Drama Schools and the Volkshochschule Kassel, and in 2012 she staged "Die Weber" by Hauptmann with amateurs in Eisenach.