Proteins involved in endocytic transit (FcsA)

• Overview (pg.1) (pg.2)
• Coronin (pg.1)(pg.2)
• Actin
• Aip 1
• FcsA
• Lysozyme
• Vacuolin (pg.1)(pg.2)
• LvsB

Top: Long chain fatty acyl CoA synthetase 1 (FcsA, green dots) on acidic endosomes and recycling vesicles.

Right: FcsA-GFP (green) on (large) endosomes and (small) recycling vesicles (both red).

Function: The uptake of fatty acids from food particles across the membrane of the endosome is inefficient in a fcsA mutant.

Reference:

• von Löhneysen, K., Pawolleck, N., Rühling, H., and Maniak, M.:
  A Dictyostelium Long Chain Fatty Acyl Coenzyme A Synthetase mediates fatty acid retrieval from endosomes. Eur.J. Cell Biol., 82, 505 - 514, 2003